Comment on "Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells" Haematologica 2011;96(9):1357-65
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چکیده
منابع مشابه
Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells.
BACKGROUND The clinical use of ex vivo-expanded T-regulatory cells for the treatment of T-cell-mediated diseases has gained increasing momentum. However, the recent demonstration that FOXP3(+) T-regulatory cells may contain interleukin-17-producing cells and that they can convert into effector cells once transferred in vivo raises significant doubts about their safety. We previously showed that...
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Thymectomy in mice on neonatal day 3 leads to the development of multiorgan autoimmune disease due to loss of a CDCD25 T cell regulatory population in their peripheral lymphoid tissues. Here, we report the identification of a CD4 population of regulatory T cells in the circulation of humans expressing high levels of CD25 that exhibit in vitro characteristics identical with those of the CD4CD25 ...
متن کاملCD4CD25 Regulatory T Cells Preventing Detrimental Autoimmune Reactions
Objective: Autoimmune diseases will occur when the immune response inflicts damage to tissues in the body. Attempts to overcome this disease have a lot to do but they have not yielded satisfying results. In this study, the function of CD4CD25 regulatory T cells was evaluated for therapeutic potential to prevent the development of autoreactive T
متن کاملDifferential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin
BACKGROUND The immunosuppressive drug rapamycin (RAPA) promotes the expansion of CD4(+) CD25(high)Foxp3(+) regulatory T cells via mechanisms that remain unknown. Here, we studied expansion, IL-2R-gamma chain signaling, survival pathways and resistance to apoptosis in human Treg responding to RAPA. METHODOLOGY/PRINCIPAL FINDINGS CD4(+)CD25(+) and CD4(+)CD25(neg) T cells were isolated from PBMC...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2012
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2011.061689